|
|
MTA-12™
: Tricyclic Antidepressants
The MTA-12™
assay for tricyclic antidepressants is designed to detect
certain structurally related compounds and to avoid
detecting others, as shown here. Of the 164 compounds tested,
only the following compounds exhibited cross reactivity
relative to the level of imipramine (ng/mL) given
below:
|
|
Concentration
(Imipramine - ng/mL)
|
|
Compounds
|
10
|
25
|
50
|
|
|
|
Amitriptyline
|
11
|
25
|
57
|
|
Chlorpromazine
|
1,180
|
1,720
|
2,550
|
|
Clomipramine
|
170
|
250
|
355
|
|
Cyclobenzaprine
|
87
|
158
|
270
|
|
Desipramine
|
5.3
|
14
|
32
|
|
Doxepin
|
195
|
345
|
590
|
|
Maprotiline
|
7.4
|
18.1
|
44
|
|
Nortriptyline
|
3.5
|
8.3
|
16.4
|
|
Perphenazine
|
4,600
|
7,100
|
10,700
|
|
Promethazine
|
8,500
|
12,300
|
18,200
|
|
Protriptyline
|
94
|
190
|
340
|
|
Trimipramine
|
255
|
490
|
980
|
|
Trifluoperzaine
|
25,000
|
34,000
|
42,500
|
|
